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Disease X-19

Disease X-19 Medical Review from Michael_Novakhov (2 sites): Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv: Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males


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Background: COVID-19 clinical presentation ranges from asymptomatic to fatal outcome. This variability is due in part to host genome specific mutations. Recently, two families in which COVID-19 segregates like an X-linked recessive monogenic disorder environmentally conditioned by SARS-CoV-2 have been reported leading to identification of loss-of-function variants in TLR7. Objective: We sought to determine whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. Methods: We compared male subjects with extreme phenotype selected from the Italian GEN-COVID cohort of 1178 SARS-CoV-2-infected subjects (
Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

Disease X-19 Medical Review from Michael_Novakhov (2 sites)